In the fast-evolving pharmaceutical industry, advancing drug discovery requires a higher level of specialized expertise and support. TME Scientific is here to partner with you on your drug discovery journey, providing the essential equipment, instruments, technologies, and tools you need for success. Our team of scientists and cutting-edge technologies deliver comprehensive support throughout every phase of your research, empowering you to make groundbreaking discoveries. We work alongside you, offering guidance and solutions before, during, and after your scientific experiments to ensure your research reaches its full potential.

TME Scientific understands the need for specialized support in today’s drug discovery efforts. Our scientists provide services that deliver predictive insights, enhancing your research process. With experts in screening, profiling, and custom assay development, we extend your team’s capabilities by offering tailored support every step of the way.

The drug discovery process begins with target identification, where scientists focus on identifying molecules like proteins or genes that play a key role in a specific disease. Once a target is pinpointed, it undergoes target validation to confirm its relevance and therapeutic potential. This step involves proving that altering the target can meaningfully impact the disease's progression. Successful validation allows the process to advance, often using cell models to study the target in a controlled environment, helping researchers observe how potential compounds affect cellular functions and disease mechanisms.

Hit identification comes next, where large libraries of compounds are screened to identify those that interact with the validated target. Techniques such as high-throughput and virtual screening are employed to uncover these "hits." Promising hits then move to hit-to-lead optimization, where compounds are refined for their potency, selectivity, and pharmacokinetic properties. Mouse models are introduced during this stage to test the compounds' efficacy and safety in vivo. These models, often genetically modified or disease-specific, provide valuable data on the pharmacodynamics and toxicity of the compounds.

Lead optimization follows, where compounds are rigorously modified to improve efficacy, reduce side effects, and enhance overall drug-like properties. The aim is to develop a high-quality lead compound ready for preclinical and clinical trials. Throughout this process, both cell and mouse models play a crucial role, offering key insights into the biological mechanisms and therapeutic potential of the compounds, which are critical for developing effective new treatments.

When standard cell models don't meet the unique demands of your research, TME Scientific's Custom Cell Model Services are here to offer a tailored solution. Our diverse portfolio of cell model assays supports a broad range of biological functions. With extensive experience in cellular engineering and custom assay development, our expert scientists are dedicated to creating the perfect model for your research needs. We provide stable cell line development for applications such as protein production, pathway analysis, and high-throughput screening. Understanding the biological context of different cells is essential, and we ensure our models align with your research objectives, timelines, and budget. Contact us to discuss how we can develop custom cell models to advance your scientific discoveries.

Target Identification & Validation

Target identification and validation are fundamental steps in drug discovery, ensuring that the chosen targets are both safe and effective while meeting clinical and commercial standards. Target identification focuses on finding specific molecules, such as proteins or genes, that are critical to the progression of a disease. Validation then confirms the therapeutic potential of modifying these targets, demonstrating their impact within a suitable timeframe. Techniques like genetic knockdown or animal models are often used to establish the target's role in the disease and to link target modulation with therapeutic benefits. This validation is vital for progressing compounds through drug development and increasing their chances of success in clinical trials.

Hit Identification and Hit-to-Lead Service

After validating a target, the next step is hit identification, where we seek out all potential compounds that can interact with and modify the target of interest. This process often involves methods such as high-throughput screening, virtual screening, or fragment-based drug discovery to efficiently identify promising candidates.

Lead identification involves a series of assays to assess the hits for their potency, selectivity, and overall quality. These hits undergo chemical evaluation and are compared through structure-activity relationship (SAR) studies, ultimately leading to the selection of the highest-quality candidates with desirable drug-like properties.

Once at least two lead series are identified, they progress to the lead optimization phase. During this stage, the pharmacological profile and drug metabolism and pharmacokinetics (DMPK) properties of the lead compounds are enhanced through chemical modifications informed by SAR studies. The objective is to refine these leads to meet the criteria set forth in the Candidate Drug Target Profile (CDTP), ensuring they qualify as potential drug candidates.

Pre-Screen Cell Banking

• Human PBMC

• Cord blood cells

• Menstrual MSC