Human IL-6
Interleukin-6 (IL-6) is a versatile cytokine involved in immune regulation, inflammation, and hematopoiesis. It is produced by macrophages, T cells, endothelial cells, and fibroblasts in response to infection or tissue damage. IL-6 triggers acute-phase responses, supports B cell differentiation into antibody-secreting plasma cells, and modulates T cell activity. Additionally, it influences the proliferation of fibroblasts and epithelial cells, contributing to tissue repair and inflammatory processes. Its role in both immune activation and regulation makes IL-6 a critical factor in normal physiology and diseases such as autoimmune disorders, chronic inflammation, and cancer.
Recombinant human IL-6 is widely used in vitro to explore cytokine signaling, immune modulation, and cellular responses. By binding to its receptor complex (IL-6R and gp130), it activates pathways such as JAK/STAT, influencing gene expression and cell behavior. It is also applied in studies on immune regulation, inflammation, and therapeutic development for conditions like rheumatoid arthritis, inflammatory bowel disease, and malignancies, aiding in drug discovery and the advancement of IL-6-targeted treatments.
| Cat. No. | RC0006 |
|---|---|
| Purity | >95% in SDS-PAGE followed by coomassie staining |
| Endotoxin Level | <0.01 EU/µg (LAL Assay) |
| Source | Purified from the culture supernatant of HEK 293 cells genetically engineered to express human IL-6 protein with a C-terminal His tag. |
| Accession # | AAA52728 |
| Applications/Intended Use | Research Use Only: This product is intended for laboratory research use only. It is not intended for any animal or human therapeutic use, any human or animal consumption, or any diagnostic use. |
| Molecular Mass | Predicted mass (19.8 kDa), appears 20-25 kDa due to glycosylation |
| Formulation | Lyophilized from a 0.1 μm filtered solution in PBS with Trehalose |
| Reconstitution | Dissolve in sterile PBS to 0.1-0.5 mg/mL or user preferred stock concentration. |
| Shipping or Handling Information | Shipped at ambient temperature |
| CoA | Batch-specific test results will be provided with the product |
| Stability | Lyophilized: Stable for 12 months at -80°C; Reconstituted: Stable for 2 weeks at 4°C, or 3-6 months at -20°C |
| Disclaimer | All of TME Scientific cell biology products are for research use ONLY and NOT for therapeutic/diagnostic applications. TME Scientific is not liable for any repercussions arising from the use of its cell biology product(s) in therapeutic/diagnostic or any other non-RUO application(s). |
