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Human Peripheral Blood B Cells

$899.00

B cells function in the adaptive immune system by producing and secreting antibodies, or incorporating them into their plasma membranes for presentation to other immune cells.  Once the antibodies in a B cell membrane encounter a "non-self" epitope of an antigen, they become activated, proliferating and maturing into effector cells that secrete more antibodies (plasma cells) for further immune response, and effector cells that are ready for quick reponse to any future infections (memory B cells).  Recent research has revealed that B cells also secrete cytokines which affect pro- and anti-inflammatory immunomodulation.  B cells (CD19+) are useful for research investigating them as cancer immunotherapy and on the treatment of autoimmune diseases using B cell depletion strategies.

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B cells function in the adaptive immune system by producing and secreting antibodies, or incorporating them into their plasma membranes for presentation to other immune cells.  Once the antibodies in a B cell membrane encounter a "non-self" epitope of an antigen, they become activated, proliferating and maturing into effector cells that secrete more antibodies (plasma cells) for further immune response, and effector cells that are ready for quick reponse to any future infections (memory B cells).  Recent research has revealed that B cells also secrete cytokines which affect pro- and anti-inflammatory immunomodulation.  B cells (CD19+) are useful for research investigating them as cancer immunotherapy and on the treatment of autoimmune diseases using B cell depletion strategies.

B cells function in the adaptive immune system by producing and secreting antibodies, or incorporating them into their plasma membranes for presentation to other immune cells.  Once the antibodies in a B cell membrane encounter a "non-self" epitope of an antigen, they become activated, proliferating and maturing into effector cells that secrete more antibodies (plasma cells) for further immune response, and effector cells that are ready for quick reponse to any future infections (memory B cells).  Recent research has revealed that B cells also secrete cytokines which affect pro- and anti-inflammatory immunomodulation.  B cells (CD19+) are useful for research investigating them as cancer immunotherapy and on the treatment of autoimmune diseases using B cell depletion strategies.

Description

B cells function in the adaptive immune system by producing and secreting antibodies, or incorporating them into their plasma membranes for presentation to other immune cells. Once the antibodies in a B cell membrane encounter a "non-self" epitope of an antigen, they become activated, proliferating and maturing into effector cells that secrete more antibodies (plasma cells) for further immune response, and effector cells that are ready for quick reponse to any future infections (memory B cells). Recent research has revealed that B cells also secrete cytokines which affect pro- and anti-inflammatory immunomodulation. B cells (CD19+) are useful for research investigating them as cancer immunotherapy and on the treatment of autoimmune diseases using B cell depletion strategies.

As a one-stop biomodeling service provider, TME offers B-cell-based in vitro model systems:

  1. To reproduce the sequential B cell differentiation into plasma cells occurring in vivo
  2. To enhance B-cell survival, proliferation, differentiation, and antibody production
  3. To assess B cell activation
  4. To test antibody production

B cells were isolated using negative immunomagnetic separation techniques and Institutional Review Board (IRB)-approved protocols and consent forms were used to acquire cells.

Specifications
Cat. No. CPB0013
Category Primary Cells
Organism Human (H. sapiens)
Tissue Peripheral Blood
Donor History Healthy Donor
Growth Properties Suspension, Round
Applications/Intended Use Research Use Only: This product is intended for laboratory research use only. It is not intended for any animal or human therapeutic use, any human or animal consumption, or any diagnostic use.
Volume/Unit 1 mL
Product Format Frozen
BioSafety II
Shipping or Handling Information Ship with dry ice
CoA Batch-specific test results will be provided with the product
Growth Conditions
  • IMDM + 10% FBS, or
  • DMEM w/ 4500mg/L D-Glucose + 10% FBS, or
  • RPMI 1640 Medium + 10% FBS
    		•
    Cryopreservation Cryopreservation Medium (Cat. No. CT002)
    Disclaimer All of TME Scientific cell biology products are for research use ONLY and NOT for therapeutic/diagnostic applications. TME Scientific is not liable for any repercussions arising from the use of its cell biology product(s) in therapeutic/diagnostic or any other non-RUO application(s).