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Human Peripheral Blood Monocytes

$979.00

Monocytes function within the innate immune system to directly destroy pathogens (phagocytosis), activate T lymphocytes (antigen presentation), stimulate inflammation (cytokine release), and maintain vascular homeostasis. They can further differentiate into macrophages, dendritic cells, and Langerhans cells, depending on the conditions.  Monocytes (CD14+) are useful for producing other cell populations via differentiation, research in cancer immunotherapy as regulators of tumor growth, and in understanding COVID-19 hyperinflammatory tissue damage.

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Monocytes function within the innate immune system to directly destroy pathogens (phagocytosis), activate T lymphocytes (antigen presentation), stimulate inflammation (cytokine release), and maintain vascular homeostasis. They can further differentiate into macrophages, dendritic cells, and Langerhans cells, depending on the conditions.  Monocytes (CD14+) are useful for producing other cell populations via differentiation, research in cancer immunotherapy as regulators of tumor growth, and in understanding COVID-19 hyperinflammatory tissue damage.

Monocytes function within the innate immune system to directly destroy pathogens (phagocytosis), activate T lymphocytes (antigen presentation), stimulate inflammation (cytokine release), and maintain vascular homeostasis. They can further differentiate into macrophages, dendritic cells, and Langerhans cells, depending on the conditions.  Monocytes (CD14+) are useful for producing other cell populations via differentiation, research in cancer immunotherapy as regulators of tumor growth, and in understanding COVID-19 hyperinflammatory tissue damage.

Description

Monocytes function within the innate immune system to directly destroy pathogens (phagocytosis), activate T lymphocytes (antigen presentation), stimulate inflammation (cytokine release), and maintain vascular homeostasis. They can further differentiate into macrophages, dendritic cells, and Langerhans cells, depending on the conditions. Monocytes (CD14+) are useful for producing other cell populations via differentiation, research in cancer immunotherapy as regulators of tumor growth, and in understanding COVID-19 hyperinflammatory tissue damage.

As a one-stop biomodeling service provider, TME offers monocytic-cell-based in vitro model systems:

  1. To assess the influence of soluble cellular mediators on DC function & phenotype (starting with monocytes)
  2. To create and assess the efficacy of monocyte-derived DC-based tumour vaccines
  3. To predict contact allergens/hazards in immunotoxicology
  4. To address the adjuvant effects of nanoparticles on the immune system based on an allogeneic co-culture model with human monocyte-derived DCs (MoDCs)

Monocytes were isolated using negative immunomagnetic separation techniques and Institutional Review Board (IRB)-approved protocols and consent forms were used to acquire cells.

Specifications
Cat. No. CPB0015
Category Primary Cells
Organism Human (H. sapiens)
Tissue Peripheral Blood
Donor History Healthy Donor
Growth Properties Adherent, irregular shape with oval or kidney shaped nucleus
Applications/Intended Use Research Use Only: This product is intended for laboratory research use only. It is not intended for any animal or human therapeutic use, any human or animal consumption, or any diagnostic use.
Volume/Unit 1 mL
Product Format Frozen
BioSafety II
Shipping or Handling Information Ship with dry ice
CoA Batch-specific test results will be provided with the product
Growth Conditions
  • IMDM + 10% FBS, or
  • DMEM w/ 4500mg/L D-Glucose + 10% FBS, or
  • RPMI 1640 Medium + 10% FBS
    		•
    Cryopreservation Cryopreservation Medium (Cat. No. CT002)
    Disclaimer All of TME Scientific cell biology products are for research use ONLY and NOT for therapeutic/diagnostic applications. TME Scientific is not liable for any repercussions arising from the use of its cell biology product(s) in therapeutic/diagnostic or any other non-RUO application(s).